all Publications

McGuire, C.K., Meehan, A.S., Couser, E., Bull, L., Minor, A.C., Kuhlmann-Hogan, A., Kaech, S.M., Shaw, R.J., Eichner, L.J. Transcriptional repression by HDAC3 mediates T cell exclusion from mutant lung tumors. (2024) Proceedings of the National Academy of Sciences of the United States of America. 121(42):e2317694121. DOI: 10.1073/pnas.2317694121

Kaymak, I., Watson, M.J., Oswald, B.M., Ma, S., Johnson, B.K., DeCamp, L.M., Mabvakure, B.M., Luda, K.M., Ma, E.H., Lau, K., Fu, Z., Muhire, B., Kitchen-Goosen, S.M., Vander Ark, A., Dahabieh, M.S., Samborska, B., Vos, M., Shen, H., Fan, Z.P., Roddy, T.P., Kingsbury, G.A., Sousa, C.M., Krawczyk, C.M., Williams, K.S., Sheldon, R.D., Kaech, S.M., Roy, D.G., Jones, R.G. ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses. (2024) Journal of Experimental Medicine. 221(9). DOI: 10.1084/jem.20231820

Mathews, I.T., Saminathan, P., Henglin, M., Liu, M., Nadig, N., Fang, C., Mercader, K., Chee, S.J., Campbell, A.M., Patel, A.A., Tiwari, S., Watrous, J.D., Ramesh, K., Dicker, M., Dao, K., Meyer, M.A., Jousilahti, P., Havulinna, A.S., Niiranen, T., Salomaa, V., Joosten, L.A.B., Netea, M.G., Zheng, P., Kronenberg, M., Patel, S.P., Gutkind, J.S., Ottensmeier, C., Long, T., Kaech, S.M., Hedrick, C.C., Cheng, S., Jain, M., Sharma, S. Linoleoyl-lysophosphatidylcholine suppresses immune-related adverse events due to immune checkpoint blockade. (2024) medRxiv. DOI: 10.1101/2024.08.07.24310974

Maxwell, M.B., Hom-Tedla, M.S., Yi, J., Li, S., Rivera, S.A., Yu, J., Burns, M.J., McRae, H.M., Stevenson, B.T., Coakley, K.E., Ho, J., Gastelum, K.B., Bell, J.C., Jones, A.C., Eskander, R.N., Dykhuizen, E.C., Shadel, G.S., Kaech, S.M., Hargreaves, D.C. ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity. (2024) Cell. DOI: 10.1016/j.cell.2024.04.025

Kuhlmann-Hogan, A., Cordes, T., Xu, Z., Kuna, R.S., Traina, K.A., Robles-Oteiza, C., Ayeni, D., Kwong, E.M., Levy, S., Globig, A.M., Nobari, M.M., Cheng, G.Z., Leibel, S.L., Homer, R.J., Shaw, R.J., Metallo, C.M., Politi, K., Kaech, S.M. EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. (2024) Cancer Discovery.:OF1-OF22 DOI: 10.1158/2159-8290.CD-23-0434

McDonald, B., Chick, B.Y., Hargreaves, D.C., Kaech, S.M. Early Chromatin Remodeling Events in Acutely Stimulated CD8 T Cells. (2023) Yale J Biol Med. 96(4):467-473. DOI: 10.59249/AXGU7370

Djureinovic, D., Weiss, S.A., Krykbaeva, I., Qu, R., Vathiotis, I., Moutafi, M., Zhang, L., Perdigoto, A.L., Wei, W., Anderson, G., Damsky, W., Hurwitz, M., Johnson, B., Schoenfeld, D., Mahajan, A., Hsu, F., Miller-Jensen, K., Kluger, Y., Sznol, M., Kaech, S.M., Bosenberg, M., Jilaveanu, L.B., Kluger, H.M. A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better. (2023) Molecular Cancer. 22(1):182. DOI: 10.1186/s12943-023-01884-x

Giles, J.R., Globig, A.M., Kaech, S.M., Wherry, E.J. CD8 T cells in the cancer-immunity cycle. (2023) Immunity. 56(10):2231-2253. DOI: 10.1016/j.immuni.2023.09.005

Mittra, S., Harding, S.M., Kaech, S.M. Memory T Cells in the Immunoprevention of Cancer: A Switch from Therapeutic to Prophylactic Approaches. (2023) Journal of Immunology. 211(6):907-916. DOI: 10.4049/jimmunol.2300049

Globig, A.M., Zhao, S., Roginsky, J., Maltez, V.I., Guiza, J., Avina-Ochoa, N., Heeg, M., Araujo Hoffmann, F., Chaudhary, O., Wang, J., Senturk, G., Chen, D., O’Connor, C., Pfaff, S., Germain, R.N., Schalper, K.A., Emu, B., Kaech, S.M. The β-adrenergic receptor links sympathetic nerves to T cell exhaustion. (2023) Nature. DOI: 10.1038/s41586-023-06568-6

Mangalhara, K.C., Varanasi, S.K., Johnson, M.A., Burns, M.J., Rojas, G.R., Esparza Moltó, P.B., Sainz, A.G., Tadepalle, N., Abbott, K.L., Mendiratta, G., Chen, D., Farsakoglu, Y., Kunchok, T., Hoffmann, F.A., Parisi, B., Rincon, M., Vander Heiden, M.G., Bosenberg, M., Hargreaves, D.C., Kaech, S.M., Shadel, G.S. Manipulating mitochondrial electron flow enhances tumor immunogenicity. (2023) Science. 381(6664):1316-1323. DOI: 10.1126/science.abq1053

Chen, D., Varanasi, S.K., Hara, T., Traina, K., Sun, M., McDonald, B., Farsakoglu, Y., Clanton, J., Xu, S., Garcia-Rivera, L., Mann, T.H., Du, V., Chung, H.K., Xu, Z., Tripple, V., Casillas, E., Ma, S., O’Connor, C., Yang, Q., Zheng, Y., Hunter, T., Lemke, G., Kaech, S.M. CTLA-4 blockade induces CD4 T cell IFNγ-driven microglial phagocytosis and anti-tumor function in glioblastoma. (2023) Immunity. DOI: 10.1016/j.immuni.2023.07.015

Krykbaeva, I., Bridges, K., Damsky, W., Pizzurro, G.A., Alexander, A.F., McGeary, M.K., Park, K., Muthusamy, V., Eyles, J., Luheshi, N., Turner, N., Weiss, S.A., Olino, K., Kaech, S.M., Kluger, H.M., Miller-Jensen, K., Bosenberg, M. Combinatorial immunotherapy with agonistic CD40 activates dendritic cells to express IL12 and overcomes PD-1 resistance. (2023) Cancer Immunology Research. DOI: 10.1158/2326-6066.CIR-22-0699

McDonald, B., Chick, B.Y., Ahmed, N.S., Burns, M., Ma, S., Casillas, E., Chen, D., Mann, T.H., O’Connor, C., Hah, N., Hargreaves, D.C., Kaech, S.M. Canonical BAF complex activity shapes the enhancer landscape that licenses CD8 T cell effector and memory fates. (2023) Immunity. 56(6):1303-1319.e5. DOI: 10.1016/j.immuni.2023.05.005

Kuhlmann-Hogan, A., Cordes, T., Xu, Z., Traina, K.A., Robles-Oteíza, C., Ayeni, D., Kwong, E.M., Levy, S.R., Nobari, M., Cheng, G.Z., Shaw, R., Leibel, S.L., Metallo, C.M., Politi, K., Kaech, S.M. EGFR lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. (2023) bioRxiv. DOI: 10.1101/2023.04.15.536974

Cable, J., Rathmell, J.C., Pearce, E.L., Ho, P.C., Haigis, M.C., Mamedov, M.R., Wu, M.J., Kaech, S.M., Lynch, L., Febbraio, M.A., Bapat, S.P., Hong, H.S., Zou, W., Belkaid, Y., Sullivan, Z.A., Keller, A., Wculek, S.K., Green, D.R., Postic, C., Amit, I., Benitah, S.A., Jones, R.G., Reina-Campos, M., Torres, S.V., Beyaz, S., Brennan, D., O’Neill, L.A.J., Perry, R.J., Brenner, D. Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report. (2023) Ann N Y Acad Sci. DOI: 10.1111/nyas.14976

Kasmani, M.Y., Zander, R., Chung, H.K., Chen, Y., Khatun, A., Damo, M., Topchyan, P., Johnson, K.E., Levashova, D., Burns, R., Lorenz, U.M., Tarakanova, V.L., Joshi, N.S., Kaech, S.M., Cui, W. Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection. (2023) Journal of Experimental Medicine. 220(1). DOI: 10.1084/jem.20220679

Tsai, C.H., Chuang, Y.M., Li, X., Yu, Y.R., Tzeng, S.F., Teoh, S.T., Lindblad, K.E., Di Matteo, M., Cheng, W.C., Hsueh, P.C., Kao, K.C., Imrichova, H., Duan, L., Gallart-Ayala, H., Hsiao, P.W., Mazzone, M., Ivanesevic, J., Liu, X., de Visser, K.E., Lujambio, A., Lunt, S.Y., Kaech, S.M., Ho, P.C. Immunoediting instructs tumor metabolic reprogramming to support immune evasion. (2023) Cell Metabolism. 35(1):118-133.e7. DOI: 10.1016/j.cmet.2022.12.003

Varanasi, S.K., Kaech, S.M., Bui, J.D. SnapShot: Cancer immunoediting. (2022) Cell. 185(21):4038-4038.e1. DOI: 10.1016/j.cell.2022.09.027

Gubbala, V.B., Jytosana, N., Trinh, V.Q., Maurer, H.C., Naeem, R.F., Lytle, N.K., Ma, Z., Zhao, S., Lin, W., Han, H., Shi, Y., Hunter, T., Singh, P.K., Olive, K.P., Tan, M.C.B., Kaech, S.M., Wahl, G.M., DelGiorno, K.E. Eicosanoids in the pancreatic tumor microenvironment – a multicellular, multifaceted progression. (2022) Gastro Hep Adv. 1(4):682-697. DOI: 10.1016/j.gastha.2022.02.007

Chaudhary, O., Trotta, D., Wang, K., Wang, X., Chu, X., Bradley, C., Okulicz, J., Maves, R.C., Kronmann, K., Schofield, C.M., Blaylock, J.M., Deng, Y., Schalper, K.A., Kaech, S.M., Agan, B., Ganesan, A., Emu, B. Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis. (2022) J Immunother Cancer. 10(4). DOI: 10.1136/jitc-2022-004564

Wang, T., Wang, Z., de Fabritus, L., Tao, J., Saied, E.M., Lee, H.J., Ramazanov, B.R., Jackson, B., Burkhardt, D., Parker, M., Gleinich, A.S., Wang, Z., Seo, D.E., Zhou, T., Xu, S., Alecu, I., Azadi, P., Arenz, C., Hornemann, T., Krishnaswamy, S., van de Pavert, S.A., Kaech, S.M., Ivanova, N.B., Santori, F.R. 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development. (2021) Developmental Cell. DOI: 10.1016/j.devcel.2021.10.018

Mann, T.H., Kaech, S.M. Counting on You: How MHC Tetramers Revolutionized the Study of T Cell Memory and CD8 T Cell Exhaustion. (2021) Journal of Immunology. 207(5):1225-1227. DOI: 10.4049/jimmunol.2100533

Robles-Oteiza, C., Ayeni, D., Levy, S., Homer, R.J., Kaech, S.M., Politi, K. Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma. (2021) Dis Model Mech. DOI: 10.1242/dmm.049072

Qian, Y., Arellano, G., Ifergan, I., Lin, J., Snowden, C., Kim, T., Thomas, J.J., Law, C., Guan, T., Balabanov, R.D., Kaech, S.M., Miller, S.D., Choi, J. ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis. (2021) Cell Reports. 36(8):109602. DOI: 10.1016/j.celrep.2021.109602

Zhao, S., Peralta, R.M., Avina-Ochoa, N., Delgoffe, G.M., Kaech, S.M. Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet. (2021) Seminars in Immunology.:101485 DOI: 10.1016/j.smim.2021.101485

Weiss, S.A., Djureinovic, D., Jessel, S., Krykbaeva, I., Zhang, L., Jilaveanu, L., Ralabate, A., Johnson, B., Shanwetter Levit, N., Anderson, G., Zelterman, D., Wei, W., Mahajan, A., Trifan, O., Bosenberg, M., Kaech, S.M., Perry, C.J., Damsky, W., Gettinger, S., Sznol, M., Hurwitz, M., Kluger, H.M. A phase I study of APX005M and cabiralizumab with/without nivolumab in patients with melanoma, kidney cancer or non-small cell lung cancer resistant to anti-PD-(L)1. (2021) Clinical Cancer Research. DOI: 10.1158/1078-0432.CCR-21-0903

Farsakoglu, Y., McDonald, B., Kaech, S.M. Motility Matters: How CD8 T-Cell Trafficking Influences Effector and Memory Cell Differentiation. (2021) Cold Spring Harbor Perspectives in Biology. DOI: 10.1101/cshperspect.a038075

Xu, S., Chaudhary, O., Rodríguez-Morales, P., Sun, X., Chen, D., Zappasodi, R., Xu, Z., Pinto, A.F.M., Williams, A., Schulze, I., Farsakoglu, Y., Varanasi, S.K., Low, J.S., Tang, W., Wang, H., McDonald, B., Tripple, V., Downes, M., Evans, R.M., Abumrad, N.A., Merghoub, T., Wolchok, J.D., Shokhirev, M.N., Ho, P.C., Witztum, J.L., Emu, B., Cui, G., Kaech, S.M. Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8 T cells in tumors. (2021) Immunity. DOI: 10.1016/j.immuni.2021.05.003

Chung, H.K., McDonald, B., Kaech, S.M. The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates. (2021) Journal of Experimental Medicine. 218(4). DOI: 10.1084/jem.20201730

Van Acker, H.H., Ma, S., Scolaro, T., Kaech, S.M., Mazzone, M. How metabolism bridles cytotoxic CD8 T cells through epigenetic modifications. (2021) Trends in Immunology. DOI: 10.1016/j.it.2021.03.006

Casanova, J.L., Holtzman, D.M., Kaech, S.M., Lanier, L.L., Nathan, C.F., Rudensky, A.Y., Tuveson, D., Wolchok, J.D. Immigration in science. (2020) Journal of Experimental Medicine. 217(11). DOI: 10.1084/jem.20202055

McGee, H.M., Marciscano, A.E., Campbell, A.M., Monjazeb, A.M., Kaech, S.M., Teijaro, J.R. Parallels between the anti-Viral State and the Irradiated State. (2020) J Natl Cancer Inst. DOI: 10.1093/jnci/djaa190

Low, J.S., Farsakoglu, Y., Amezcua Vesely, M.C., Sefik, E., Kelly, J.B., Harman, C.C.D., Jackson, R., Shyer, J.A., Jiang, X., Cauley, L.S., Flavell, R.A., Kaech, S.M. Tissue-resident memory T cell reactivation by diverse antigen-presenting cells imparts distinct functional responses. (2020) Journal of Experimental Medicine. 217(8). DOI: 10.1084/jem.20192291

DelGiorno, K.E., Chung, C.Y., Vavinskaya, V., Maurer, H.C., Novak, S.W., Lytle, N.K., Ma, Z., Giraddi, R.R., Wang, D., Fang, L., Naeem, R.F., Andrade, L.R., Ali, W.H., Tseng, H., Tsui, C., Gubbala, V.B., Ridinger-Saison, M., Ohmoto, M., Erikson, G.A., O’Connor, C., Shokhirev, M.N., Hah, N., Urade, Y., Matsumoto, I., Kaech, S.M., Singh, P.K., Manor, U., Olive, K.P., Wahl, G.M. Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2. (2020) Gastroenterology. DOI: 10.1053/j.gastro.2020.07.037

Starrett, J.H., Guernet, A.A., Cuomo, M.E., Poels, K.E., van Alderwerelt van Rosenburgh, I.K., Nagelberg, A., Farnsworth, D., Price, K.S., Khan, H., Ashtekar, K.D., Gaefele, M., Ayeni, D., Stewart, T.F., Kuhlmann, A., Kaech, S., Unni, A.M., Homer, R., Lockwood, W.W., Michor, F., Goldberg, S.B., Lemmon, M.A., Smith, P.D., Cross, D.A., Politi, K. Drug sensitivity and allele-specificity of first-line osimertinib resistance EGFR mutations. (2020) Cancer Research. DOI: 10.1158/0008-5472.CAN-19-3819

O’Garra, A., Belkaid, Y., Sharpe, A., Kaech, S., Cherry, S., Passegué, E. JEM women in STEM: Unique journeys with a common purpose. (2020) Journal of Experimental Medicine. 217(3). DOI: 10.1084/jem.20200254

Avey, S., Mohanty, S., Chawla, D.G., Meng, H., Bandaranayake, T., Ueda, I., Zapata, H.J., Park, K., Blevins, T.P., Tsang, S., Belshe, R.B., Kaech, S.M., Shaw, A.C., Kleinstein, S.H. Seasonal Variability and Shared Molecular Signatures of Inactivated Influenza Vaccination in Young and Older Adults. (2020) Journal of Immunology. 204(6):1661-1673. DOI: 10.4049/jimmunol.1900922

Crotty, S., Blish, C., Cadwell, K., Chi, H., Goldrath, A., Green, D., Kaech, S.M., Krummel, M., Pepper, M., Rothlin, C.V., Wherry, E.J., . Reinvigorating NIH Grant Peer Review. (2020) Immunity. 52(1):1-3. DOI: 10.1016/j.immuni.2019.12.016

Wu, Z., Oeck, S., West, A.P., Mangalhara, K.C., Sainz, A.G., Newman, L.E., Zhang, X.O., Wu, L., Yan, Q., Bosenberg, M., Liu, Y., Sulkowski, P.L., Tripple, V., Kaech, S.M., Glazer, P.M., Shadel, G.S. Mitochondrial DNA Stress Signalling Protects the Nuclear Genome. (2019) Nature Metabolism. 1(12):1209-1218. DOI: 10.1038/s42255-019-0150-8

Varanasi, S.K., Ma, S., Kaech, S.M. T Cell Metabolism in a State of Flux. (2019) Immunity. 51(5):783-785. DOI: 10.1016/j.immuni.2019.10.012

Harel, M., Ortenberg, R., Varanasi, S.K., Mangalhara, K.C., Mardamshina, M., Markovits, E., Baruch, E.N., Tripple, V., Arama-Chayoth, M., Greenberg, E., Shenoy, A., Ayasun, R., Knafo, N., Xu, S., Anafi, L., Yanovich-Arad, G., Barnabas, G.D., Ashkenazi, S., Besser, M.J., Schachter, J., Bosenberg, M., Shadel, G.S., Barshack, I., Kaech, S.M., Markel, G., Geiger, T. Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence. (2019) Cell. DOI: 10.1016/j.cell.2019.08.012

Mann, T.H., Kaech, S.M. Tick-TOX, it’s time for T cell exhaustion (2019) Nature Immunology. 20(9):1092-1094. DOI: 10.1038/s41590-019-0478-y

Ayeni, D., Miller, B., Kuhlmann, A., Ho, P.C., Robles-Oteiza, C., Gaefele, M., Levy, S., de Miguel, F.J., Perry, C., Guan, T., Krystal, G., Lockwood, W., Zelterman, D., Homer, R., Liu, Z., Kaech, S., Politi, K. Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors. (2019) Journal for Immunotherapy of Cancer. 7(1):172. DOI: 10.1186/s40425-019-0643-8

Myers, L.M., Tal, M.C., Torrez Dulgeroff, L.B., Carmody, A.B., Messer, R.J., Gulati, G., Yiu, Y.Y., Staron, M.M., Angel, C.L., Sinha, R., Markovic, M., Pham, E.A., Fram, B., Ahmed, A., Newman, A.M., Glenn, J.S., Davis, M.M., Kaech, S.M., Weissman, I.L., Hasenkrug, K.J. A functional subset of CD8 T cells during chronic exhaustion is defined by SIRPα expression. (2019) Nature Communications. 10(1):794. DOI: 10.1038/s41467-019-08637-9

Kaech, S.M. T-bet in Tfh cells: Now you see me, now you don’t. (2018) J. Exp. Med.:2697-2698 DOI: 10.1084/jem.20181878

Fan, M.Y., Low, J.S., Tanimine, N., Finn, K.K., Priyadharshini, B., Germana, S.K., Kaech, S.M., Turka, L.A. Differential Roles of IL-2 Signaling in Developing versus Mature Tregs. (2018) Cell Reports. 25(5):1204-1213.e4. DOI: 10.1016/j.celrep.2018.10.002

Arojo, O.A., Ouyang, X., Liu, D., Meng, T., Kaech, S.M., Pereira, J.P., Su, B. Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression. (2018) Journal of Immunology. 201(3):908-915. DOI: 10.4049/jimmunol.1800529

Gettinger, S.N., Wurtz, A., Goldberg, S.B., Rimm, D., Schalper, K., Kaech, S., Kavathas, P., Chiang, A., Lilenbaum, R., Zelterman, D., Politi, K., Herbst, R.S. Clinical Features and Management of Acquired Resistance to PD-1 Axis Inhibitors in 26 Patients With Advanced Non-Small Cell Lung Cancer. (2018) J Thorac Oncol. 13(6):831-839. DOI: 10.1016/j.jtho.2018.03.008

Pereira, F.V., Melo, A.C.L., Low, J.S., de Castro, I.A., Braga, T.T., Almeida, D.C., Batista de Lima, A.G.U., Hiyane, M.I., Correa-Costa, M., Andrade-Oliveira, V., Origassa, C.S.T., Pereira, R.M., Kaech, S.M., Rodrigues, E.G., Câmara, N.O.S. Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response. (2018) Oncotarget. 9(40):25808-25825. DOI: 10.18632/oncotarget.25380

Herndler-Brandstetter, D., Ishigame, H., Shinnakasu, R., Plajer, V., Stecher, C., Zhao, J., Lietzenmayer, M., Kroehling, L., Takumi, A., Kometani, K., Inoue, T., Kluger, Y., Kaech, S.M., Kurosaki, T., Okada, T., Flavell, R.A. KLRG1 Effector CD8 T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. (2018) Immunity. 48(4):716-729.e8. DOI: 10.1016/j.immuni.2018.03.015

Guan, T., Dominguez, C.X., Amezquita, R.A., Laidlaw, B.J., Cheng, J., Henao-Mejia, J., Williams, A., Flavell, R.A., Lu, J., Kaech, S.M. ZEB1, ZEB2, and the miR-200 family form a counterregulatory network to regulate CD8 T cell fates. (2018) Journal of Experimental Medicine. 215(4):1153-1168. DOI: 10.1084/jem.20171352

Perry, C.J., Muñoz-Rojas, A.R., Meeth, K.M., Kellman, L.N., Amezquita, R.A., Thakral, D., Du, V.Y., Wang, J.X., Damsky, W., Kuhlmann, A.L., Sher, J.W., Bosenberg, M., Miller-Jensen, K., Kaech, S.M. Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. (2018) Journal of Experimental Medicine. 215(3):877-893. DOI: 10.1084/jem.20171435

Low, J.S., Kaech, S.M. Trials and Tribble-ations of tissue T cells. (2018) Nature Immunology. 19(2):102-103. DOI: 10.1038/s41590-017-0031-9

Weinstein, J.S., Laidlaw, B.J., Lu, Y., Wang, J.K., Schulz, V.P., Li, N., Herman, E.I., Kaech, S.M., Gallagher, P.G., Craft, J. STAT4 and T-bet control follicular helper T cell development in viral infections. (2018) Journal of Experimental Medicine. 215(1):337-355. DOI: 10.1084/jem.20170457

Gettinger, S., Choi, J., Hastings, K., Truini, A., Datar, I., Sowell, R., Wurtz, A., Dong, W., Cai, G., Melnick, M.A., Du, V.Y., Schlessinger, J., Goldberg, S.B., Chiang, A., Sanmamed, M.F., Melero, I., Agorreta, J., Montuenga, L.M., Lifton, R., Ferrone, S., Kavathas, P., Rimm, D.L., Kaech, S.M., Schalper, K., Herbst, R.S., Politi, K. Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer. (2017) Cancer Discovery. 7(12):1420-1435. DOI: 10.1158/2159-8290.CD-17-0593

Laidlaw, B.J., Lu, Y., Amezquita, R.A., Weinstein, J.S., Vander Heiden, J.A., Gupta, N.T., Kleinstein, S.H., Kaech, S.M., Craft, J. Interleukin-10 from CD4 follicular regulatory T cells promotes the germinal center response. (2017) Science Immunology. 2(16). DOI: 10.1126/sciimmunol.aan4767

Yeon, S.M., Halim, L., Chandele, A., Perry, C.J., Kim, S.H., Kim, S.U., Byun, Y., Yuk, S.H., Kaech, S.M., Jung, Y.W. IL-7 plays a critical role for the homeostasis of allergen-specific memory CD4 T cells in the lung and airways. (2017) Scientific Reports. 7(1):11155. DOI: 10.1038/s41598-017-11492-7

Shin, H.M., Kapoor, V.N., Kim, G., Li, P., Kim, H.R., Suresh, M., Kaech, S.M., Wherry, E.J., Selin, L.K., Leonard, W.J., Welsh, R.M., Berg, L.J. Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory. (2017) PLOS pathogens. 13(8):e1006544. DOI: 10.1371/journal.ppat.1006544

Roberts, N.A., Adams, B.D., McCarthy, N.I., Tooze, R.M., Parnell, S.M., Anderson, G., Kaech, S.M., Horsley, V. Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity. (2017) Journal of Immunology. 199(4):1250-1260. DOI: 10.4049/jimmunol.1600941

Wang, J., Perry, C.J., Meeth, K., Thakral, D., Damsky, W., Micevic, G., Kaech, S., Blenman, K., Bosenberg, M. UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model. (2017) Pigment Cell & Melanoma Research. 30(4):428-435. DOI: 10.1111/pcmr.12591

Ho, P.C., Kaech, S.M. Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries. (2017) Current Opinion in Immunology. 46:38-44. DOI: 10.1016/j.coi.2017.04.003

Buck, M.D., Sowell, R.T., Kaech, S.M., Pearce, E.L. Metabolic Instruction of Immunity. (2017) Cell. 169(4):570-586. DOI: 10.1016/j.cell.2017.04.004

Hajek, M., Sewell, A., Kaech, S., Burtness, B., Yarbrough, W.G., Issaeva, N. TRAF3/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma. (2017) Cancer. 123(10):1778-1790. DOI: 10.1002/cncr.30570

Gray, S.M., Amezquita, R.A., Guan, T., Kleinstein, S.H., Kaech, S.M. Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8 T Cell Terminal Differentiation and Loss of Multipotency. (2017) Immunity. 46(4):596-608. DOI: 10.1016/j.immuni.2017.03.012

Amezquita, R.A., Kaech, S.M. Immunology: The chronicles of T-cell exhaustion. (2017) Nature. 543(7644):190-191. DOI: 10.1038/nature21508

Poholek, A.C., Jankovic, D., Villarino, A.V., Petermann, F., Hettinga, A., Shouval, D.S., Snapper, S.B., Kaech, S.M., Brooks, S.R., Vahedi, G., Sher, A., Kanno, Y., O’Shea, J.J. IL-10 induces a STAT3-dependent autoregulatory loop in T2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. (2016) Science Immunology. 1(5). DOI: DOI: 10.1126/sciimmunol.aaf8612

Adams, N.M., O’Sullivan, T.E., Geary, C.D., Karo, J.M., Amezquita, R.A., Joshi, N.S., Kaech, S.M., Sun, J.C. NK Cell Responses Redefine Immunological Memory. (2016) Journal of Immunology. 197(8):2963-2970. DOI: 10.4049/jimmunol.1600973

Boddupalli, C.S., Nair, S., Gray, S.M., Nowyhed, H.N., Verma, R., Gibson, J.A., Abraham, C., Narayan, D., Vasquez, J., Hedrick, C.C., Flavell, R.A., Dhodapkar, K.M., Kaech, S.M., Dhodapkar, M.V. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. (2016) Journal of Clinical Investigation. 126(10):3905-3916. DOI: 10.1172/JCI85329

Sowell, R.T., Kaech, S.M. Probing the Diversity of T Cell Dysfunction in Cancer. (2016) Cell. 166(6):1362-1364. DOI: 10.1016/j.cell.2016.08.058

Kritikou, J.S., Dahlberg, C.I., Baptista, M.A., Wagner, A.K., Banerjee, P.P., Gwalani, L.A., Poli, C., Panda, S.K., Kärre, K., Kaech, S.M., Wermeling, F., Andersson, J., Orange, J.S., Brauner, H., Westerberg, L.S. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. (2016) Scientific Reports. 6:30636. DOI: 10.1038/srep30636

Jung, Y.W., Kim, H.G., Perry, C.J., Kaech, S.M. CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent niches. (2016) Proceedings of the National Academy of Sciences of the United States of America. 113(29):8278-83. DOI: 10.1073/pnas.1602899113

Garyu, J.W., Uduman, M., Stewart, A., Rui, J., Deng, S., Shenson, J., Staron, M.M., Kaech, S.M., Kleinstein, S.H., Herold, K.C. Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE. (2016) Journal of Biological Chemistry. 291(21):11230-40. DOI: 10.1074/jbc.M115.713362

Xin, A., Masson, F., Liao, Y., Preston, S., Guan, T., Gloury, R., Olshansky, M., Lin, J.X., Li, P., Speed, T.P., Smyth, G.K., Ernst, M., Leonard, W.J., Pellegrini, M., Kaech, S.M., Nutt, S.L., Shi, W., Belz, G.T., Kallies, A. A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet. (2016) Nature Immunology. 17(4):422-32. DOI: 10.1038/ni.3410

Laidlaw, B.J., Craft, J.E., Kaech, S.M. The multifaceted role of CD4(+) T cells in CD8(+) T cell memory. (2016) Nature Reviews. Immunology. 16(2):102-11. DOI: 10.1038/nri.2015.10

Dominguez, C.X., Amezquita, R.A., Guan, T., Marshall, H.D., Joshi, N.S., Kleinstein, S.H., Kaech, S.M. The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. (2015) J. Exp. Med. 212(12):2041-56. DOI: 10.1084/jem.20150186

Ray, J.P., Staron, M.M., Shyer, J.A., Ho, P.C., Marshall, H.D., Gray, S.M., Laidlaw, B.J., Araki, K., Ahmed, R., Kaech, S.M., Craft, J. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. (2015) Immunity. 43(4):690-702. DOI: 10.1016/j.immuni.2015.08.017

Ho, P.C., Bihuniak, J.D., Macintyre, A.N., Staron, M., Liu, X., Amezquita, R., Tsui, Y.C., Cui, G., Micevic, G., Perales, J.C., Kleinstein, S.H., Abel, E.D., Insogna, K.L., Feske, S., Locasale, J.W., Bosenberg, M.W., Rathmell, J.C., Kaech, S.M. Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. (2015) Cell. 162(6):1217-28. DOI: 10.1016/j.cell.2015.08.012

Laidlaw, B.J., Cui, W., Amezquita, R.A., Gray, S.M., Guan, T., Lu, Y., Kobayashi, Y., Flavell, R.A., Kleinstein, S.H., Craft, J., Kaech, S.M. Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells. (2015) Nature Immunology. 16(8):871-9. DOI: 10.1038/ni.3224

Cui, G., Staron, M.M., Gray, S.M., Ho, P.C., Amezquita, R.A., Wu, J., Kaech, S.M. IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity. (2015) Cell. 161(4):750-61. DOI: 10.1016/j.cell.2015.03.021

West, A.P., Khoury-Hanold, W., Staron, M., Tal, M.C., Pineda, C.M., Lang, S.M., Bestwick, M., Duguay, B.A., Raimundo, N., MacDuff, D.A., Kaech, S.M., Smiley, J.R., Means, R.E., Iwasaki, A., Shadel, G.S. Mitochondrial DNA stress primes the antiviral innate immune response. (2015) Nature. 520(7548):553-7. DOI: 10.1038/nature14156

Chen, J.H., Perry, C.J., Tsui, Y.C., Staron, M.M., Parish, I.A., Dominguez, C.X., Rosenberg, D.W., Kaech, S.M. Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection. (2015) Nature Medicine. 21(4):327-34. DOI: 10.1038/nm.3831

Mohanty, S., Joshi, S.R., Ueda, I., Wilson, J., Blevins, T.P., Siconolfi, B., Meng, H., Devine, L., Raddassi, K., Tsang, S., Belshe, R.B., Hafler, D.A., Kaech, S.M., Kleinstein, S.H., Trentalange, M., Allore, H.G., Shaw, A.C. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults. (2015) J. Infect. Dis. 211(7):1174-84. DOI: 10.1093/infdis/jiu573

Hu, Y., Lee, Y.T., Kaech, S.M., Garvy, B., Cauley, L.S. Smad4 promotes differentiation of effector and circulating memory CD8 T cells but is dispensable for tissue-resident memory CD8 T cells. (2015) Journal of immunology. 194(5):2407-14. DOI: 10.4049/jimmunol.1402369

Perry, R.J., Camporez, J.G., Kursawe, R., Titchenell, P.M., Zhang, D., Perry, C.J., Jurczak, M.J., Abudukadier, A., Han, M.S., Zhang, X.M., Ruan, H.B., Yang, X., Caprio, S., Kaech, S.M., Sul, H.S., Birnbaum, M.J., Davis, R.J., Cline, G.W., Petersen, K.F., Shulman, G.I. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. (2015) Cell. 160(4):745-758. DOI: 10.1016/j.cell.2015.01.012

Thakar, J., Mohanty, S., West, A.P., Joshi, S.R., Ueda, I., Wilson, J., Meng, H., Blevins, T.P., Tsang, S., Trentalange, M., Siconolfi, B., Park, K., Gill, T.M., Belshe, R.B., Kaech, S.M., Shadel, G.S., Kleinstein, S.H., Shaw, A.C. Aging-dependent alterations in gene expression and a mitochondrial signature of responsiveness to human influenza vaccination. (2015) Aging. 7(1):38-52. DOI: 10.18632/aging.100720

Marshall, H.D., Ray, J.P., Laidlaw, B.J., Zhang, N., Gawande, D., Staron, M.M., Craft, J., Kaech, S.M. The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa. (2015) Elife. 4:e04851. DOI: 10.7554/eLife.04851

Backer, R.A., Helbig, C., Gentek, R., Kent, A., Laidlaw, B.J., Dominguez, C.X., de Souza, Y.S., van Trierum, S.E., van Beek, R., Rimmelzwaan, G.F., ten Brinke, A., Willemsen, A.M., van Kampen, A.H., Kaech, S.M., Blander, J.M., van Gisbergen, K., Amsen, D. A central role for Notch in effector CD8(+) T cell differentiation. (2014) Nature Immunology. 15(12):1143-51. DOI: 10.1038/ni.3027

Staron, M.M., Gray, S.M., Marshall, H.D., Parish, I.A., Chen, J.H., Perry, C.J., Cui, G., Li, M.O., Kaech, S.M. The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection. (2014) Immunity. 41(5):802-14. DOI: 10.1016/j.immuni.2014.10.013

Laidlaw, B.J., Zhang, N., Marshall, H.D., Staron, M.M., Guan, T., Hu, Y., Cauley, L.S., Craft, J., Kaech, S.M. CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. (2014) Immunity. 41(4):633-45. DOI: 10.1016/j.immuni.2014.09.007

Shaw, P.J., Weidinger, C., Vaeth, M., Luethy, K., Kaech, S.M., Feske, S. CD4⁺ and CD8⁺ T cell-dependent antiviral immunity requires STIM1 and STIM2. (2014) Journal of Clinical Investigation. 124(10):4549-63. DOI: 10.1172/JCI76602

Gray, S.M., Kaech, S.M., Staron, M.M. The interface between transcriptional and epigenetic control of effector and memory CD8⁺ T-cell differentiation. (2014) Immunol. Rev. 261(1):157-68. DOI: 10.1111/imr.12205

Gate, D., Danielpour, M., Rodriguez, J., Kim, G.B., Levy, R., Bannykh, S., Breunig, J.J., Kaech, S.M., Flavell, R.A., Town, T. T-cell TGF-β signaling abrogation restricts medulloblastoma progression. (2014) Proceedings of the National Academy of Sciences of the United States of America. 111(33):E3458-66. DOI: 10.1073/pnas.1412489111

Marshall, H.D., Kaech, S.M. Regulating the diverse outcomes of interferon’s interference. (2014) Trends in Immunology. 35(8):353-4. DOI: 10.1016/j.it.2014.07.002

Parish, I.A., Marshall, H.D., Staron, M.M., Lang, P.A., Brüstle, A., Chen, J.H., Cui, W., Tsui, Y.C., Perry, C., Laidlaw, B.J., Ohashi, P.S., Weaver, C.T., Kaech, S.M. Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. (2014) Journal of Clinical Investigation. 124(8):3455-68. DOI: 10.1172/JCI66108

Ho, P.C., Kaech, S.M. BRAF-targeted therapy alters the functions of intratumoral CD4 T cells to inhibit melanoma progression. (2014) Oncoimmunology. 3:e29126. DOI: 10.4161/onci.29126

Cui, W., Joshi, N.S., Liu, Y., Meng, H., Kleinstein, S.H., Kaech, S.M. TLR4 ligands lipopolysaccharide and monophosphoryl lipid a differentially regulate effector and memory CD8+ T Cell differentiation. (2014) Journal of immunology. 192(9):4221-32. DOI: 10.4049/jimmunol.1302569

Ray, J.P., Marshall, H.D., Laidlaw, B.J., Staron, M.M., Kaech, S.M., Craft, J. Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells. (2014) Immunity. 40(3):367-77. DOI: 10.1016/j.immuni.2014.02.005

Kaech, S.M. Celebrating diversity in memory T cells. (2014) Journal of Immunology. 192(3):837-9. DOI: 10.4049/jimmunol.1303268

Zhao, Y., Zhao, H., Sun, Y., Hao, J., Qi, X., Zhou, X., Wu, Z., Wang, P., Kaech, S.M., Weaver, C.T., Flavell, R.A., Zhao, L., Yao, Z., Yin, Z. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. (2013) Journal of Leukocyte Biology. 94(6):1103-12. DOI: 10.1189/jlb.0213064

Slütter, B., Pewe, L.L., Kaech, S.M., Harty, J.T. Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus. (2013) Immunity. 39(5):939-48. DOI: 10.1016/j.immuni.2013.09.013

Shin, H.M., Kapoor, V., Guan, T., Kaech, S.M., Welsh, R.M., Berg, L.J. Epigenetic modifications induced by Blimp-1 Regulate CD8⁺ T cell memory progression during acute virus infection. (2013) Immunity. 39(4):661-75. DOI: 10.1016/j.immuni.2013.08.032

Marshall, H.D., Kaech, S.M. Generating CD8 T cell heterogeneity: attack of the clones. (2013) Immunity. 39(2):203-5. DOI: 10.1016/j.immuni.2013.08.008

Henao-Mejia, J., Williams, A., Goff, L.A., Staron, M., Licona-Limón, P., Kaech, S.M., Nakayama, M., Rinn, J.L., Flavell, R.A. The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. (2013) Immunity. 38(5):984-97. DOI: 10.1016/j.immuni.2013.02.021

D’Souza, A.D., Parish, I.A., Krause, D.S., Kaech, S.M., Shadel, G.S. Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia. (2013) Molecular Therapy. 21(1):42-8. DOI: 10.1038/mt.2012.203

Kaech, S.M., Cui, W. Transcriptional control of effector and memory CD8+ T cell differentiation. (2012) Nature Reviews. Immunology. 12(11):749-61. DOI: 10.1038/nri3307

Demento, S.L., Cui, W., Criscione, J.M., Stern, E., Tulipan, J., Kaech, S.M., Fahmy, T.M. Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. (2012) Biomaterials. 33(19):4957-64. DOI: 10.1016/j.biomaterials.2012.03.041

Lang, P.A., Lang, K.S., Xu, H.C., Grusdat, M., Parish, I.A., Recher, M., Elford, A.R., Dhanji, S., Shaabani, N., Tran, C.W., Dissanayake, D., Rahbar, R., Ghazarian, M., Brüstle, A., Fine, J., Chen, P., Weaver, C.T., Klose, C., Diefenbach, A., Häussinger, D., Carlyle, J.R., Kaech, S.M., Mak, T.W., Ohashi, P.S. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. (2012) Proceedings of the National Academy of Sciences of the United States of America. 109(4):1210-5. DOI: 10.1073/pnas.1118834109

Cui, W., Liu, Y., Weinstein, J.S., Craft, J., Kaech, S.M. An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. (2011) Immunity. 35(5):792-805. DOI: 10.1016/j.immuni.2011.09.017

Li, N., Matte-Martone, C., Zheng, H., Cui, W., Venkatesan, S., Tan, H.S., McNiff, J., Demetris, A.J., Roopenian, D., Kaech, S., Shlomchik, W.D. Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. (2011) Blood. 118(22):5965-76. DOI: 10.1182/blood-2011-07-367011

Marshall, H.D., Chandele, A., Jung, Y.W., Meng, H., Poholek, A.C., Parish, I.A., Rutishauser, R., Cui, W., Kleinstein, S.H., Craft, J., Kaech, S.M. Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection. (2011) Immunity. 35(4):633-46. DOI: 10.1016/j.immuni.2011.08.016

Joshi, N.S., Cui, W., Dominguez, C.X., Chen, J.H., Hand, T.W., Kaech, S.M. Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells. (2011) Journal of immunology. 187(8):4068-76. DOI: 10.4049/jimmunol.1002145

D’Souza, A.D., Parish, I.A., McKay, S.E., Kaech, S.M., Shadel, G.S. Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. (2011) American Journal of Pathology. 178(6):2740-51. DOI: 10.1016/j.ajpath.2011.02.022

Parish, I.A., Kaech, S.M. IL-7 knocks the socs off chronic viral infection. (2011) Cell. 144(4):467-8. DOI: 10.1016/j.cell.2011.01.038

Jung, Y.W., Rutishauser, R.L., Joshi, N.S., Haberman, A.M., Kaech, S.M. Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. (2010) Journal of immunology. 185(9):5315-25. DOI: 10.4049/jimmunol.1001948

Jung, Y.W., Kaech, S.M. Like parent, like child: inheritance of effector CD8+ T cell traits. (2010) Immunity. 33(3):296-8. DOI: 10.1016/j.immuni.2010.09.005

Hand, T.W., Cui, W., Jung, Y.W., Sefik, E., Joshi, N.S., Chandele, A., Liu, Y., Kaech, S.M. Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival. (2010) Proceedings of the National Academy of Sciences of the United States of America. 107(38):16601-6. DOI: 10.1073/pnas.1003457107

Demento, S.L., Bonafé, N., Cui, W., Kaech, S.M., Caplan, M.J., Fikrig, E., Ledizet, M., Fahmy, T.M. TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. (2010) Journal of Immunology. 185(5):2989-97. DOI: 10.4049/jimmunol.1000768

Cui, W., Kaech, S.M. Generation of effector CD8+ T cells and their conversion to memory T cells. (2010) Immunological Reviews. 236:151-66. DOI: 10.1111/j.1600-065X.2010.00926.x

Poholek, A.C., Hansen, K., Hernandez, S.G., Eto, D., Chandele, A., Weinstein, J.S., Dong, X., Odegard, J.M., Kaech, S.M., Dent, A.L., Crotty, S., Craft, J. In vivo regulation of Bcl6 and T follicular helper cell development. (2010) Journal of Immunology. 185(1):313-26. DOI: 10.4049/jimmunol.0904023

Rutishauser, R.L., Kaech, S.M. Generating diversity: transcriptional regulation of effector and memory CD8 T-cell differentiation. (2010) Immunol. Rev. 235(1):219-33. DOI: 10.1111/j.0105-2896.2010.00901.x

Hinson, E.R., Joshi, N.S., Chen, J.H., Rahner, C., Jung, Y.W., Wang, X., Kaech, S.M., Cresswell, P. Viperin is highly induced in neutrophils and macrophages during acute and chronic lymphocytic choriomeningitis virus infection. (2010) Journal of immunology. 184(10):5723-31. DOI: 10.4049/jimmunol.0903752

Rutishauser, R.L., Martins, G.A., Kalachikov, S., Chandele, A., Parish, I.A., Meffre, E., Jacob, J., Calame, K., Kaech, S.M. Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. (2009) Immunity. 31(2):296-308. DOI: 10.1016/j.immuni.2009.05.014

Parish, I.A., Kaech, S.M. Diversity in CD8(+) T cell differentiation. (2009) Current Opinion in Immunology. 21(3):291-7. DOI: 10.1016/j.coi.2009.05.008

Hand, T.W., Kaech, S.M. Intrinsic and extrinsic control of effector T cell survival and memory T cell development. (2009) Immunologic Research. 45(1):46-61. DOI: 10.1007/s12026-008-8027-z

Cui, W., Joshi, N.S., Jiang, A., Kaech, S.M. Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. (2009) Vaccine. 27(15):2177-87. DOI: 10.1016/j.vaccine.2009.01.088

Whitmire, J.K., Asano, M.S., Kaech, S.M., Sarkar, S., Hannum, L.G., Shlomchik, M.J., Ahmed, R. Requirement of B cells for generating CD4+ T cell memory. (2009) Journal of Immunology. 182(4):1868-76. DOI: 10.4049/jimmunol.0802501

Rahman, A.H., Cui, W., Larosa, D.F., Taylor, D.K., Zhang, J., Goldstein, D.R., Wherry, E.J., Kaech, S.M., Turka, L.A. MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. (2008) Journal of immunology. 181(6):3804-10.

Haining, W.N., Ebert, B.L., Subrmanian, A., Wherry, E.J., Eichbaum, Q., Evans, J.W., Mak, R., Rivoli, S., Pretz, J., Angelosanto, J., Smutko, J.S., Walker, B.D., Kaech, S.M., Ahmed, R., Nadler, L.M., Golub, T.R. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. (2008) Journal of immunology. 181(3):1859-68.

Chandele, A., Joshi, N.S., Zhu, J., Paul, W.E., Leonard, W.J., Kaech, S.M. Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. (2008) Journal of Immunology. 180(8):5309-19.

Joshi, N.S., Kaech, S.M. Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation. (2008) Journal of Immunology. 180(3):1309-15.

D’Souza, A.D., Parikh, N., Kaech, S.M., Shadel, G.S. Convergence of multiple signaling pathways is required to coordinately up-regulate mtDNA and mitochondrial biogenesis during T cell activation. (2007) Mitochondrion. 7(6):374-85. DOI: 10.1016/j.mito.2007.08.001

Wu, H., Yuan, M., Kaech, S.M., Halloran, E. A statistical analysis of memory CD8 T cell differentiation: An application of a hierarchical state space model to a short time course microarray experiment (2007) Annals of Applied Statistics. 1(2):442-458. DOI: doi:10.1214/07-AOAS118

Wherry, E.J., Ha, S.J., Kaech, S.M., Haining, W.N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J.N., Barber, D.L., Ahmed, R. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. (2007) Immunity. 27(4):670-84. DOI: 10.1016/j.immuni.2007.09.006

Kaech, S.M., Wherry, E.J. Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007) Immunity. 27(3):393-405. DOI: 10.1016/j.immuni.2007.08.007

Joshi, N.S., Cui, W., Chandele, A., Lee, H.K., Urso, D.R., Hagman, J., Gapin, L., Kaech, S.M. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. (2007) Immunity. 27(2):281-95. DOI: 10.1016/j.immuni.2007.07.010

Hand, T.W., Morre, M., Kaech, S.M. Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. (2007) Proceedings of the National Academy of Sciences of the United States of America. 104(28):11730-5. DOI: 10.1073/pnas.0705007104

Tesar, B.M., Walker, W.E., Unternaehrer, J., Joshi, N.S., Chandele, A., Haynes, L., Kaech, S., Goldstein, D.R. Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. (2006) Aging Cell. 5(6):473-86. DOI: 10.1111/j.1474-9726.2006.00245.x

Intlekofer, A.M., Takemoto, N., Wherry, E.J., Longworth, S.A., Northrup, J.T., Palanivel, V.R., Mullen, A.C., Gasink, C.R., Kaech, S.M., Miller, J.D., Gapin, L., Ryan, K., Russ, A.P., Lindsten, T., Orange, J.S., Goldrath, A.W., Ahmed, R., Reiner, S.L. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. (2005) Nature Immunology. 6(12):1236-44. DOI: 10.1038/ni1268

Gao, Y., Tao, J., Li, M.O., Zhang, D., Chi, H., Henegariu, O., Kaech, S.M., Davis, R.J., Flavell, R.A., Yin, Z. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. (2005) Journal of immunology. 175(9):5783-9.

Chandele, A., Kaech, S.M. Cutting edge: memory CD8 T cell maturation occurs independently of CD8alphaalpha. (2005) Journal of immunology. 175(9):5619-23.

Manders, P.M., Hunter, P.J., Telaranta, A.I., Carr, J.M., Marshall, J.L., Carrasco, M., Murakami, Y., Palmowski, M.J., Cerundolo, V., Kaech, S.M., Ahmed, R., Fearon, D.T. BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes. (2005) Proceedings of the National Academy of Sciences of the United States of America. 102(21):7418-25. DOI: 10.1073/pnas.0501585102

Paiardini, M., Cervasi, B., Albrecht, H., Muthukumar, A., Dunham, R., Gordon, S., Radziewicz, H., Piedimonte, G., Magnani, M., Montroni, M., Kaech, S.M., Weintrob, A., Altman, J.D., Sodora, D.L., Feinberg, M.B., Silvestri, G. Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals. (2005) Journal of immunology. 174(5):2900-9.

Wherry, E.J., Barber, D.L., Kaech, S.M., Blattman, J.N., Ahmed, R. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. (2004) Proceedings of the National Academy of Sciences of the United States of America. 101(45):16004-9. DOI: 10.1073/pnas.0407192101

Sabbagh, L., Kaech, S.M., Bourbonnière, M., Woo, M., Cohen, L.Y., Haddad, E.K., Labrecque, N., Ahmed, R., Sékaly, R.P. The selective increase in caspase-3 expression in effector but not memory T cells allows susceptibility to apoptosis. (2004) Journal of immunology. 173(9):5425-33.

Latner, D.R., Kaech, S.M., Ahmed, R. Enhanced expression of cell cycle regulatory genes in virus-specific memory CD8+ T cells. (2004) Journal of Virology. 78(20):10953-9. DOI: 10.1128/JVI.78.20.10953-10959.2004

Masopust, D., Kaech, S.M., Wherry, E.J., Ahmed, R. The role of programming in memory T-cell development. (2004) Current Opinion in Immunology. 16(2):217-25. DOI: 10.1016/j.coi.2004.02.005

Kaech, S.M., Tan, J.T., Wherry, E.J., Konieczny, B.T., Surh, C.D., Ahmed, R. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. (2003) Nature Immunology. 4(12):1191-8. DOI: 10.1038/ni1009

Wan, J., Martinvalet, D., Ji, X., Lois, C., Kaech, S.M., Von Andrian, U.H., Lieberman, J., Ahmed, R., Manjunath, N. The Bcl-2 family pro-apoptotic molecule, BNIP3 regulates activation-induced cell death of effector cytotoxic T lymphocytes. (2003) Immunology. 110(1):10-7.

Adams, A.B., Williams, M.A., Jones, T.R., Shirasugi, N., Durham, M.M., Kaech, S.M., Wherry, E.J., Onami, T., Lanier, J.G., Kokko, K.E., Pearson, T.C., Ahmed, R., Larsen, C.P. Heterologous immunity provides a potent barrier to transplantation tolerance. (2003) Journal of Clinical Investigation. 111(12):1887-95. DOI: 10.1172/JCI17477

Kersh, E.N., Kaech, S.M., Onami, T.M., Moran, M., Wherry, E.J., Miceli, M.C., Ahmed, R. TCR signal transduction in antigen-specific memory CD8 T cells. (2003) Journal of Immunology. 170(11):5455-63.

Blattman, J.N., Grayson, J.M., Wherry, E.J., Kaech, S.M., Smith, K.A., Ahmed, R. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. (2003) Nature Medicine. 9(5):540-7. DOI: 10.1038/nm866

Antia, R., Bergstrom, C.T., Pilyugin, S.S., Kaech, S.M., Ahmed, R. Models of CD8+ responses: 1. What is the antigen-independent proliferation program. (2003) Journal of Theoretical Biology. 221(4):585-98.

Kaech, S.M., Ahmed, R. Immunology. CD8 T cells remember with a little help. (2003) Science. 300(5617):263-5. DOI: 10.1126/science.1084511

Wherry, E.J., Teichgräber, V., Becker, T.C., Masopust, D., Kaech, S.M., Antia, R., von Andrian, U.H., Ahmed, R. Lineage relationship and protective immunity of memory CD8 T cell subsets. (2003) Nature Immunology. 4(3):225-34. DOI: 10.1038/ni889

Shen, H., Whitmire, J.K., Fan, X., Shedlock, D.J., Kaech, S.M., Ahmed, R. A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes. (2003) Journal of immunology. 170(3):1443-51.

Hathcock, K.S., Kaech, S.M., Ahmed, R., Hodes, R.J. Induction of telomerase activity and maintenance of telomere length in virus-specific effector and memory CD8+ T cells. (2003) Journal of Immunology. 170(1):147-52.

Kaech, S.M., Hemby, S., Kersh, E., Ahmed, R. Molecular and functional profiling of memory CD8 T cell differentiation. (2002) Cell. 111(6):837-51.

Kaech, S.M., Wherry, E.J., Ahmed, R. Effector and memory T-cell differentiation: implications for vaccine development. (2002) Nature Reviews. Immunology. 2(4):251-62. DOI: 10.1038/nri778

Blattman, J.N., Antia, R., Sourdive, D.J., Wang, X., Kaech, S.M., Murali-Krishna, K., Altman, J.D., Ahmed, R. Estimating the precursor frequency of naive antigen-specific CD8 T cells. (2002) Journal of Experimental Medicine. 195(5):657-64.

Kaech, S.M., Ahmed, R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. (2001) Nature Immunology. 2(5):415-22. DOI: 10.1038/87720

Perego, C., Vanoni, C., Villa, A., Longhi, R., Kaech, S.M., Fröhli, E., Hajnal, A., Kim, S.K., Pietrini, G. PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells. (1999) EMBO Journal. 18(9):2384-93. DOI: 10.1093/emboj/18.9.2384

Borg, J.P., Straight, S.W., Kaech, S.M., de Taddéo-Borg, M., Kroon, D.E., Karnak, D., Turner, R.S., Kim, S.K., Margolis, B. Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. (1998) Journal of Biological Chemistry. 273(48):31633-6.

Kaech, S.M., Whitfield, C.W., Kim, S.K. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. (1998) Cell. 94(6):761-71.

Simske, J.S., Kaech, S.M., Harp, S.A., Kim, S.K. LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. (1996) Cell. 85(2):195-204. DOI: 0.1016/s0092-8674(00)81096-x