Salk scientists receive 2022 Mark Foundation Endeavor Award to study lung cancer
LA JOLLA—Professors Reuben Shaw, Susan Kaech, Christian Metallo and Alan Saghatelian have received a 2022 Mark Foundation for Cancer Research Endeavor Award to support their research exploring the metabolic changes that help lung cancers develop. The $3 million Endeavor Award promotes collaborative science to tackle some of the toughest challenges in cancer research. The Salk team—one of four teams chosen out of nearly 200 applications submitted by institutions around the world—hopes their work will lead to the development of more effective lung cancer treatments.
Salk Institute among cross-collaborative teams gifted $220 million by Wu Tsai Human Performance Alliance
LA JOLLA—A Salk Institute team led by Professor Satchin Panda, along with teams from five other organizations, have been awarded a total of $220 million by the Joe and Clara Tsai Foundation’s Human Performance Alliance, whose philanthropic investment aims to transform human health on a global scale through the discovery and translation of the biological principles underlying human performance.
“Bad fat” suppresses killer T cells from attacking cancer
LA JOLLA—In order for cancer to grow and spread, it has to evade detection by our immune cells, particularly specialized “killer” T cells. Salk researchers led by Professor Susan Kaech have found that the environment inside tumors (the tumor microenvironment) contains an abundance of oxidized fat molecules, which, when ingested by the killer T cells, suppresses their ability to kill cancer cells. In a vicious cycle, those T cells, in need of energy, increase the level of a cellular fat transporter, CD36, that unfortunately saturates them with even more oxidized fat and further curtails their anti-tumor functions.
Salk’s NOMIS Center receives $9.5 million to shape the future of research into health and immunity
LA JOLLA—As we endure a global viral pandemic, our appreciation for health and immunity has never been greater. Now, thanks to a generous gift from the NOMIS Foundation, Salk’s NOMIS Center for Immunobiology and Microbial Pathogenesis will receive $9.5 million to grow and expand, while continuing to be a leader in health and immunity research.
Salk Professors Susan Kaech and Alan Saghatelian named 2020 AAAS Fellows
LA JOLLA—Salk Professors Susan Kaech and Alan Saghatelian have been named 2020 Fellows of the American Association for the Advancement of Science (AAAS), the world’s largest general scientific society and publisher of the journal Science. Kaech and Saghatelian are among 489 new AAAS Fellows who were nominated by their peers for their distinguished efforts to advance science.
Salk researchers accelerate, expand COVID-19 research
LA JOLLA—As the COVID-19 pandemic continues across the globe, the Salk Institute joins in efforts to understand the fundamental science behind the novel coronavirus to pave the way to treatments and cures. COVID-19 exploits a vulnerability in the immune system’s armor: because the SARS-CoV-2 virus—the novel coronavirus that causes COVID-19—appeared in humans recently, our immune systems have no experience with the virus—and sometimes have difficulty fighting it.
How targeting killer T cells in the lungs could lead to immunity against respiratory viruses
LA JOLLA—A significant site of damage during COVID-19 infection is the lungs. Understanding how the lungs’ immune cells are responding to viral infections could help scientists develop a vaccine.
Salk awarded $19.2 million by the American Heart Association-Allen Initiative to study Alzheimer’s and aging in the brain
LA JOLLA—A team of Salk Institute researchers led by President Rusty Gage has been awarded $19.2 million over eight years by the American Heart Association-Allen Initiative in Brain Health and Cognitive Impairment to investigate mechanisms underlying Alzheimer’s disease and aging-related cognitive decline and uncover new therapies. This bold venture will comprehensively analyze interactions between five areas key to brain health: proteins, genes, metabolism, inflammation and epigenetics.
Salk Institute launches Conquering Cancer Initiative
LA JOLLA—On Friday, April 20, 2018, the Salk Institute launched a new initiative called Conquering Cancer, to harness specific and emerging scientific strategies to tackle the five deadliest cancers: pancreatic, ovarian, lung, brain (glioblastoma) and triple-negative breast.
Prominent scientists in immunobiology and aging research to join Salk Institute
LA JOLLA—The Salk Institute is honored to welcome two new faculty with the rank of full professor, both of whom are highly respected and accomplished leaders in their fields. Susan Kaech and Gerald Shadel will inspire fresh collaborations and bring experienced perspectives to bear on Salk’s approaches to health and disease.